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J Neurocrit Care 2011;4(2): 60-62.
뇌들보와 대뇌운동피질을 침범한 Marchiafava-Bignami 병 1예
서울의료원 신경과
A Case of Marchiafava-Bignami Disease Involved Corpus Callosum and Cerebral Motor Cortex
Min-Jae Seong, MD, Soo-Ji Lee, MD, Joon-Hyung Lee, MD and Jae-Hyeok Heo, MD
Department of Neurology, Seoul Medical Center, Seoul, Korea
Background: Marchiafava-bignami disease (MBD) is a neurologic condition that presents with variable neurologic symptoms. MBD usually involves the corpus callosum and results in demyelination and necrosis. However, we report a case of MBD showed cortical involvement as well as callosal lesion.
Case Report: A 36-year-old man was found with altered mental status on a street. The past medical history could not be obtained, but he appeared to be a chronic alcoholic with significant malnutrition. On neurologic exam, he was confused, aphasic with dysarthria, and ataxic. On diffusion-weighted imaging, bilateral frontal cortical and corpus callosal lesions were found. He was diagnosed with MBD, and was started on IV thiamine therapy. After 2 months, he was discharged with improved neurologic status.
Conclusions: MBD is a slowly progressive disease that’s been reported to result in high mortality. The prognosis is especially grave with cortical involvement. However, the case presented above showed favorable prognosis.
Key Words: Marchiafava-bignami disease · Cerebral cortex · Corpus callosum
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