1. Neu HC. Safety of cefepime: a new extended-spectrum parenteral cephalosporin. Am J Med 1996;100(6A):68S-75S.
2. Wong KM, Chan WK, Chan YH, Li CS. Cefepime-related neurotoxicity in a haemodialysis patient. Nephrol Dial Transplant 1999;14:2265-6.
3. Jallon P, Fankhauser L, Du Pasquier R, Coeytaux A, Picard F, Hefft S, et al. Severe but reversible encephalopathy associated with cefepime. Neurophysiol Clin 2000;30:383-6.
4. Garces EO, Andrade de Anzambuja MF, da Silva D, Bragatti JA, Jacoby T, Saldanha Thomé F. Renal failure is a risk factor for cefepime-induced encephalopathy. J Nephrol 2008;21:526-34.
6. Fugate JE, Kalimullah EA, Hocker SE, Clark SL, Wijdicks EF, Rabinstein AA. Cefepime neurotoxicity in the intensive care unit: a cause of severe, underappreciated encephalopathy. Crit Care 2013;17:R264.
7. Sutter R, Rüegg S, Tschudin-Sutter S. Seizures as adverse events of antibiotic drugs: a systematic review. Neurology 2015;85:1332-41.
10. Payne LE, Gagnon DJ, Riker RR, Seder DB, Glisic EK, Morris JG, et al. Cefepime-induced neurotoxicity: a systematic review. Crit Care 2017;21:276.
11. Cho KH. Antibiotics induced seizures and encephalopathy. J Neurocrit Care 2018;11:1-6.
12. Saurina A, Vera M, Pou M, López Pedret J, Darnell A, Campistol JM, et al. Non-convulsive status epilepticus secondary to adjusted cefepime doses in patients with chronic renal failure. Nefrologia 2000;20:554-8.
13. Martínez-Rodríguez JE, Barriga FJ, Santamaria J, Iranzo A, Pareja JA, Revilla M, et al. Nonconvulsive status epilepticus associated with cephalosporins in patients with renal failure. Am J Med 2001;111:115-9.
14. Ferrara N, Abete P, Giordano M, Ferrara P, Carnovale V, Leosco D, et al. Neurotoxicity induced by cefepime in a very old hemodialysis patient. Clin Nephrol 2003;59:388-90.
15. De Silva DA, Pan AB, Lim SH. Cefepime-induced encephalopathy with triphasic waves in three Asian patients. Ann Acad Med Singapore 2007;36:450-1.
16. Gangireddy VG, Mitchell LC, Coleman T. Cefepime neurotoxicity despite renal adjusted dosing. Scand J Infect Dis 2011;43:827-9.
17. Nakagawa R, Sato K, Uesaka Y, Mitsuki T, Kondo K, Wake A, et al. Cefepime-induced encephalopathy in end-stage renal disease patients. J Neurol Sci 2017;376:123-8.
18. Li HT, Lee CH, Wu T, Cheng MY, Tseng WJ, Chang CW, et al. Clinical, electroencephalographic features and prognostic factors of cefepime-induced neurotoxicity: a retrospective study. Neurocrit Care 2019;31:329-37.
19. Capparelli FJ, Diaz MF, Hlavnika A, Wainsztein NA, Leiguarda R, Del Castillo ME. Cefepime- and cefixime-induced encephalopathy in a patient with normal renal function. Neurology 2005;65:1840.
20. Fernández-Torre JL, Martínez-Martínez M, González-Rato J, Maestro I, Alonso I, Rodrigo E, et al. Cephalosporin-induced nonconvulsive status epilepticus: clinical and electroencephalographic features. Epilepsia 2005;46:1550-2.
22. Meillier A, Rahimian D. Cefepime-induced encephalopathy with normal renal function. Oxf Med Case Reports 2016;2016:118-20.
23. U.S. Food and Drug Administration. FDA Drug Safety Communication: cefepime and risk of seizure in patients not receiving dosage adjustments for kidney impairment [Internet]. Silver Spring (MD): FDA; 2016 [cited 2019 Dec 16]. Available from:
http://www.fda.gov/Drugs/DrugSafety/ucm309661.htm.
24. Ugai T, Morisaki K, Tsuda K, Sugihara H, Nishida Y, Yamakura M, et al. Cefepime-induced encephalopathy in patients with haematological malignancies: clinical features and risk factors. Scand J Infect Dis 2014;46:272-9.
26. Lamoth F, Buclin T, Pascual A, Vora S, Bolay S, Decosterd LA, et al. High cefepime plasma concentrations and neurological toxicity in febrile neutropenic patients with mild impairment of renal function. Antimicrob Agents Chemother 2010;54:4360-7.
27. Huwyler T, Lenggenhager L, Abbas M, Ing Lorenzini K, Hughes S, Huttner B, et al. Cefepime plasma concentrations and clinical toxicity: a retrospective cohort study. Clin Microbiol Infect 2017;23:454-9.
28. Boschung-Pasquier L, Atkinson A, Kastner LK, Banholzer S, Haschke M, Buetti N, et al. Cefepime neurotoxicity: thresholds and risk factors: a retrospective cohort study. Clin Microbiol Infect 2019 July 5
https://doi.org/10.1016/j.cmi.2019.06.028.
29. Lacroix C, Kheloufi F, Montastruc F, Bennis Y, Pizzoglio V, Micallef J. Serious central nervous system side effects of cephalosporins: a national analysis of serious reports registered in the French Pharmacovigilance Database. J Neurol Sci 2019;398:196-201.
32. Barbhaiya RH, Forgue ST, Gleason CR, Knupp CA, Pittman KA, Weidler DJ, et al. Safety, tolerance, and pharmacokinetic evaluation of cefepime after administration of single intravenous doses. Antimicrob Agents Chemother 1990;34:1118-22.
34. Barbhaiya RH, Knupp CA, Pfeffer M, Zaccardelli D, Dukes GM, Mattern W, et al. Pharmacokinetics of cefepime in patients undergoing continuous ambulatory peritoneal dialysis. Antimicrob Agents Chemother 1992;36:1387-91.
35. U.S. Food and Drug Administration. Cefepime (marketed as Maxipime) update of ongoing safety review [Internet]. Silver Spring (MD): FDA; 2009 [cited 2019 Dec 16]. Available from:
https://www.fda.gov/.
37. De Sarro A, Ammendola D, Zappala M, Grasso S, De Sarro GB. Relationship between structure and convulsant properties of some beta-lactam antibiotics following intracerebroventricular microinjection in rats. Antimicrob Agents Chemother 1995;39:232-7.
38. Grill MF, Maganti R. Cephalosporin-induced neurotoxicity: clinical manifestations, potential pathogenic mechanisms, and the role of electroencephalographic monitoring. Ann Pharmacother 2008;42:1843-50.
39. Kim SH, Nam YH, Jeon DS, Lee HW, Nam HJ, Lee SK. Cefepime-induced encephalopathy without renal impairment. Allergy Asthma Respir Dis 2014;2:213-7.
40. Park HM, Noh Y, Yang JW, Shin DH, Lee YB. Cefepime-induced non-convulsive status epilepticus in a patient with normal renal function. J Epilepsy Res 2016;6:97-9.
42. Lee JY, Kang KP, Kim W, Park SK, Lee S. An overlooked cause of impaired consciousness in a hemodialysis patient. Korean J Intern Med 2012;27:367.
43. Triplett JD, Lawn ND, Chan J, Dunne JW. Cephalosporin-related neurotoxicity: metabolic encephalopathy or non-convulsive status epilepticus? J Clin Neurosci 2019;67:163-6.
44. Fishman RA. Blood-brain and CSF barriers to penicillin and related organic acids. Arch Neurol 1966;15:113-24.
45. Chatellier D, Jourdain M, Mangalaboyi J, Ader F, Chopin C, Derambure P, et al. Cefepime-induced neurotoxicity: an underestimated complication of antibiotherapy in patients with acute renal failure. Intensive Care Med 2002;28:214-7.
47. Obermeier B, Daneman R, Ransohoff RM. Development, maintenance and disruption of the blood-brain barrier. Nat Med 2013;19:1584-96.
48. Abanades S, Nolla J, Rodríguez-Campello A, Pedro C, Valls A, Farré M. Reversible coma secondary to cefepime neurotoxicity. Ann Pharmacother 2004;38:606-8.
50. Seyler L, Cotton F, Taccone FS, De Backer D, Macours P, Vincent JL, et al. Recommended β-lactam regimens are inadequate in septic patients treated with continuous renal replacement therapy. Crit Care 2011;15:R137.
51. Lam S, Gomolin IH. Cefepime neurotoxicity: case report, pharmacokinetic considerations, and literature review. Pharmacotherapy 2006;26:1169-74.
52. Rhodes NJ, Kuti JL, Nicolau DP, Neely MN, Nicasio AM, Scheetz MH. An exploratory analysis of the ability of a cefepime trough concentration greater than 22 mg/L to predict neurotoxicity. J Infect Chemother 2016;22:78-83.
53. Hirsch LJ, LaRoche SM, Gaspard N, Gerard E, Svoronos A, Herman ST, et al. American Clinical Neurophysiology Society's standardized critical care EEG terminology: 2012 version. J Clin Neurophysiol 2013;30:1-27.
54. Hartshorn JA, Foreman B. Generalized periodic discharges with triphasic morphology. J Neurocrit Care 2019;12:1-8.
55. Lee S. Pregabalin intoxication-induced encephalopathy with triphasic waves. Epilepsy Behav 2012;25:170-3.
56. Kifune A, Kubota F, Shibata N, Akata T, Kikuchi S. Valproic acid-induced hyperammonemic encephalopathy with triphasic waves. Epilepsia 2000;41:909-12.
57. Dike GL. Triphasic waves in serotonin syndrome. J Neurol Neurosurg Psychiatry 1997;62:200.
58. Hormes JT, Benarroch EE, Rodriguez M, Klass DW. Periodic sharp waves in baclofen-induced encephalopathy. Arch Neurol 1988;45:814-5.
59. Kaplan PW, Birbeck G. Lithium-induced confusional states: nonconvulsive status epilepticus or triphasic encephalopathy? Epilepsia 2006;47:2071-4.
60. Neufeld MY. Periodic triphasic waves in levodopa-induced encephalopathy. Neurology 1992;42:444-6.
61. Lancman ME, Marks S, Mahmood K, Lansen T. Atypical triphasic waves associated with the use of pentobarbital. Electroencephalogr Clin Neurophysiol 1997;102:175-7.
62. de Borchgrave V, Lienard F, Willemart T, van Rijckevorsel K. Clinical and EEG findings in six patients with altered mental status receiving tiagabine therapy. Epilepsy Behav 2003;4:326-37.
63. Vulliemoz S, Iwanowski P, Landis T, Jallon P. Levetiracetam accumulation in renal failure causing myoclonic encephalopathy with triphasic waves. Seizure 2009;18:376-8.
64. Kaplan PW, Sutter R. Affair with triphasic waves-their striking presence, mysterious significance, and cryptic origins: what are they? J Clin Neurophysiol 2015;32:401-5.
65. Beniczky S, Hirsch LJ, Kaplan PW, Pressler R, Bauer G, Aurlien H, et al. Unified EEG terminology and criteria for nonconvulsive status epilepticus. Epilepsia 2013;54 Suppl 6:28-9.
66. Trinka E, Leitinger M. Which EEG patterns in coma are nonconvulsive status epilepticus? Epilepsy Behav 2015;49:203-22.
67. Bauer G, Trinka E. Nonconvulsive status epilepticus and coma. Epilepsia 2010;51:177-90.
68. Young GB, Jordan KG, Doig GS. An assessment of nonconvulsive seizures in the intensive care unit using continuous EEG monitoring: an investigation of variables associated with mortality. Neurology 1996;47:83-9.
69. Lee SJ. A comatose patient with continuous generalized 3 Hz spike-and-wave discharges after cardiac arrest. J Korean Neurol Assoc 2015;33:209-12.
70. Bragatti JA, Rossato R, Ziomkowski S, Kliemann FA. Cefepime-induced encephalopathy: clinical and electroencephalographic features in seven patients. Arq Neuropsiquiatr 2005;63:87-92.
71. Sonck J, Laureys G, Verbeelen D. The neurotoxicity and safety of treatment with cefepime in patients with renal failure. Nephrol Dial Transplant 2008;23:966-70.
72. Lin CJ, Chen SP, Wang SJ, Fuh JL. Cefepime-related encephalopathy in peritoneal dialysis patients. J Chin Med Assoc 2011;74:87-90.
73. Shirota Y, Ohtomo R, Hanajima R, Terao Y, Tsutsumi R, Tsuji S. Severely abnormal electroencephalogram in two patients who were treated with cefepime. Rinsho Shinkeigaku 2012;52:356-9.
74. Mani LY, Kissling S, Viceic D, Vogt B, Burnier M, Buclin T, et al. Intermittent hemodialysis treatment in cefepime-induced neurotoxicity: case report, pharmacokinetic modeling, and review of the literature. Hemodial Int 2015;19:333-43.
75. Toda Y, Yamazaki M, Ota T, Fujisawa Y, Kimura K. A case of cefepime encephalopathy, being difficult to distinguish from non-convulsive status epilepticus during the treatment of bacterial meningitis. Rinsho Shinkeigaku 2016;56:678-83.
76. Tchapyjnikov D, Luedke MW. Cefepime-induced encephalopathy and nonconvulsive status epilepticus: dispelling an artificial dichotomy. Neurohospitalist 2019;9:100-4.
77. Dixit S, Kurle P, Buyan-Dent L, Sheth RD. Status epilepticus associated with cefepime. Neurology 2000;54:2153-5.
78. Chow KM, Wang AY, Hui AC, Wong TY, Szeto CC, Li PK. Nonconvulsive status epilepticus in peritoneal dialysis patients. Am J Kidney Dis 2001;38:400-5.
79. Plensa E, Gallardo E, Ribera JM, Batlle M, Oriol A, Costa J. Nonconvulsive status epilepticus associated with cefepime in a patient undergoing autologous stem cell transplantation. Bone Marrow Transplant 2004;33:119-20.
80. Primavera A, Cocito L, Audenino D. Nonconvulsive status epilepticus during cephalosporin therapy. Neuropsychobiology 2004;49:218-22.
81. Chang YM. Cefepime-induced nonconvulsive status epilepticus as a cause of confusion in an elderly patient. J Formos Med Assoc 2015;114:290-1.
83. Bora I, Demir AB, Uzun P. Nonconvulsive status epilepticus cases arising in connection with cephalosporins. Epilepsy Behav Case Rep 2016;6:23-7.
84. Anuhya V, Kunder SK, Madhyastha S, Nayak V, Acharya RV, Ramamoorthi K, et al. Looking beyond the obvious: cefepime-induced nonconvulsive status epilepticus. J Pharmacol Pharmacother 2017;8:145-7.
85. Fountain NB, Waldman WA. Effects of benzodiazepines on triphasic waves: implications for nonconvulsive status epilepticus. J Clin Neurophysiol 2001;18:345-52.
86. Brigo F, Storti M. Triphasic waves. Am J Electroneurodiagnostic Technol 2011;51:16-25.
90. Lee GH. Cefepime induced non-convulsive status epilepticus (NCSE). J Pusan Natl Univ Hosp 2014;36:185-9.
91. Yahav D, Paul M, Fraser A, Sarid N, Leibovici L. Efficacy and safety of cefepime: a systematic review and meta-analysis. Lancet Infect Dis 2007;7:338-48.
92. Kim PW, Wu YT, Cooper C, Rochester G, Valappil T, Wang Y, et al. Meta-analysis of a possible signal of increased mortality associated with cefepime use. Clin Infect Dis 2010;51:381-9.